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Update on Targeted Therapies for Advanced Non-Small Cell Lung Cancer: Durvalumab in Context
Sneha Gullapalli1, Jordi Remon2, Lizza E L Hendriks3
1Division of Pulmonary and Critical Care, University of Miami, Jackson Memorial Hospital, Miami, FL, USA.
Abstract:
Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death ligand 1 inhibitor) is the unique drug approved as consolidation treatment after chemo-radiotherapy. This article reviews the pharmacological properties, clinical activity and safety of durvalumab as monotherapy or in combination with chemotherapy or other ICIs in the therapeutic strategy of NSCLC patients.
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