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Long Non-Coding RNAs in Drug Resistance of Breast Cancer
Tonghua Du1, Ying Shi1, Shengnan Xu1
1Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Oncotargets and Therapy
|August 9, 2020
Summary
Long non-coding RNAs (lncRNAs) drive breast cancer drug resistance through complex mechanisms. Targeting these lncRNAs offers a promising strategy to overcome treatment failure in breast cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer (BC) remains a leading cause of cancer death in women.
- Therapeutic advancements have improved outcomes, but drug resistance limits efficacy.
- Long non-coding RNAs (lncRNAs) play a critical role in BC progression and treatment resistance.
Purpose of the Study:
- To review current knowledge on lncRNA mechanisms in BC drug resistance.
- To explore the clinical potential of lncRNAs as therapeutic targets for overcoming BC resistance.
Main Methods:
- Literature review of recent studies on lncRNAs and BC drug resistance.
- Analysis of molecular mechanisms by which lncRNAs modulate drug resistance.
- Discussion of emerging therapeutic strategies targeting lncRNAs in BC.
Main Results:
- lncRNAs contribute to BC drug resistance through diverse molecular pathways.
- Specific lncRNAs have been identified as key regulators of resistance to various therapies.
- lncRNAs are implicated in chemoresistance, endocrine resistance, and targeted therapy resistance.
Conclusions:
- lncRNAs are crucial mediators of drug resistance in breast cancer.
- Targeting lncRNAs presents a novel therapeutic avenue to improve treatment outcomes for BC patients.
- Further research into lncRNA functions can pave the way for personalized medicine approaches in BC treatment.
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