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Thyroid Hormone Changes in Euthyroid Patients with Diabetes.

Ken Qin1, Fan Zhang1, Qinqin Wu1

  • 1Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|August 9, 2020
PubMed
Summary
This summary is machine-generated.

In euthyroid adults, diabetes is linked to an increased ratio of free thyroxine (FT4) to free triiodothyronine (FT3). This finding suggests altered peripheral thyroid hormone metabolism in individuals with diabetes.

Keywords:
diabetes mellitusthyroid hormonesthyroxinetriiodothyronine

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Clinical Research

Background:

  • Thyroid dysfunction is a known comorbidity of diabetes.
  • However, the specific changes in thyroid hormone levels among euthyroid adults with diabetes remain unclear.

Purpose of the Study:

  • To investigate the association between thyroid hormone levels and diabetes in euthyroid adults.
  • To explore differences in thyroid hormone profiles between newly diagnosed and previously diagnosed diabetes.

Main Methods:

  • A cross-sectional study of 32,557 euthyroid adults from West China Hospital (2016).
  • Diabetes was identified using medical history, fasting blood glucose, and HbA1c.
  • Thyroid hormone levels (TSH, FT4, FT3) and FT4/FT3 ratio were compared between diabetic and non-diabetic groups, and within diabetes subgroups (NDD vs. PDD).

Main Results:

  • Diabetes was associated with significantly higher FT4/FT3 ratios (OR 2.05) and FT4 levels (OR 1.11) compared to controls.
  • Individuals with previously diagnosed diabetes (PDD) showed a higher FT4/FT3 ratio (OR 1.76) compared to those with newly diagnosed diabetes (NDD).
  • Thyroid stimulating hormone (TSH) and free triiodothyronine (FT3) levels were lower in the diabetic group.

Conclusions:

  • Diabetes in euthyroid adults is associated with an elevated FT4/FT3 ratio.
  • This suggests a potential alteration in peripheral thyroid hormone turnover in diabetic individuals.
  • The findings highlight the complex interplay between thyroid hormones and diabetes.