Related Experiment Video
Updated: Dec 12, 2025
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for
Zhao-Hua Wang1, Chang Shu2, Xiao Ran1
1Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Insights
Older age, arrhythmia, and high Sequential Organ Failure Assessment (SOFA) scores are key indicators for mortality risk in critically ill patients with COVID-19. Early medical intervention is crucial for these high-risk individuals.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Epidemiology
Background:
- The COVID-19 pandemic has a significant global mortality rate.
- Prognostic factors for severe COVID-19 cases remain incompletely understood.
- Identifying predictors of mortality is crucial for managing critically ill patients.
Purpose of the Study:
- To identify significant prognostic factors associated with mortality in intensive care unit (ICU) patients diagnosed with COVID-19.
- To elucidate demographic, clinical, and laboratory predictors of adverse outcomes in severe COVID-19.
Main Methods:
- A cohort of 59 critically ill COVID-19 patients from an ICU was analyzed.
- Comprehensive data including epidemiological, demographic, clinical, laboratory, and radiological information were collected.
- Statistical analysis was performed to define prognostic factors for patient mortality.
Main Results:
- The study included patients aged 67.4±11.3 years; 51 had comorbidities, and 41 died.
- Deceased patients were older, had more smoking history, fatigue, diarrhea, organ injuries, lymphopenia, thrombocytopenia, impaired immunity, and heightened cytokine release compared to survivors.
- Independent risk factors for mortality included age >70 years (OR=2.76), arrhythmia (OR=4.76), and SOFA score >4 (OR=5.16).
Conclusions:
- Critically ill COVID-19 patients over 70 years old, those with arrhythmia, or a SOFA score above 4 face a high mortality risk.
- These identified factors necessitate prioritized medical intervention and closer monitoring.
- Understanding these prognostic factors can guide clinical decision-making and resource allocation in managing severe COVID-19.
Background:
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic outbreak with a high mortality. Prognostic factors of critically ill patients with COVID-19 have not been fully elucidated yet.
Methods:
In the present study, 59 patients with COVID-19 from the intensive care unit of the Caidian Branch of Tongji Hospital were enrolled. Epidemiological, demographic, clinical, laboratory, radiological, treatment data, and clinical outcomes were collected. Prognostic factors were statistically defined.
Results:
Of the 59 patients studied (67.4±11.3 years), 38 patients were male, 51 had underlying diseases, and 41 patients died during admission. Compared with the survivors, the deceased patients were of older age, had more smoking history, severer fatigue, and diarrhea, a higher incidence of multiple organ injuries, more deteriorative lymphopenia and thrombocytopenia, remarkably impaired cellular immune response, and strengthened cytokine release. Age higher than 70 (OR=2.76, 95% CI=1.45-5.23), arrhythmia (OR=4.76, 95% CI=1.59-14.25), and a Sequential Organ Failure Assessment (SOFA) score above 4 (OR=5.16, 95% CI=1.29-20.55) were identified as risk factors for mortality of patients.
Conclusion:
Critically ill COVID-19 patients aged higher than 70, arrhythmia, or a SOFA score above 4 have a high risk of mortality, and need prior medical intervention.
Related Concept Videos
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:30Pneumonia III: Complications and Assessment
01:21Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
01:30Acute Respiratory Failure-III
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...