Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ContinuumAEP and the acquisition of competencies in Pediatrics.

Anales de pediatria·2025

Same author

Pediatric critical care admission after scoliosis surgery in children with underlying conditions: requirements, evolution and comparison with healthy children.

International journal of orthopaedic and trauma nursing·2025

Same author

Cardiac arrest in a previously healthy infant caused by secondary pseudohypoaldosteronism: Case report and literature review.

Medicina intensiva·2025

Same author

Why did you ask so many questions?

Palliative & supportive care·2025

Same author

Severe Mycoplasma Pneumoniae Infections During the 2023-2024 Outbreak: A Single-Center Descriptive Study in a Pediatric Intensive Care.

The Pediatric infectious disease journal·2025

Same author

Effectiveness and Safety of Cidofovir Treatment for Severe Adenovirus Pneumonia in Immunocompetent Pediatric Patients.

The Pediatric infectious disease journal·2025

Search research articles

Related Experiment Video

Updated: Dec 12, 2025

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

Normal fecal calprotectin levels in healthy children are higher than in adults and decrease with age.

Marta Velasco Rodríguez-Belvís¹, Javier Francisco Viada Bris¹, Carmen Plata Fernández²

¹Gastroenterology and Nutrition Department, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.

Paediatrics & Child Health

|August 9, 2020

Summary

Pediatric fecal calprotectin (FC) levels are higher in infants and decrease with age. This study established normal FC ranges in healthy children, finding age is the primary factor influencing levels.

Keywords:

Children Fecal calprotectin Healthy

More Related Videos

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Related Experiment Videos

Last Updated: Dec 12, 2025

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Area of Science:

Pediatric Gastroenterology
Clinical Biochemistry

Background:

Establishing reliable pediatric reference ranges for fecal calprotectin (FC) is crucial due to wide age-related variability.
Factors such as anthropometrics and feeding type may influence FC levels in children.

Purpose of the Study:

To establish normal fecal calprotectin (FC) levels in healthy children, stratified by age.
To investigate the influence of sex, gestational age, birth weight, delivery type, feeding type, and anthropometric data on pediatric FC values.

Main Methods:

A multicenter, cross-sectional, observational study included 395 healthy children under 18 years.
Exclusion criteria focused on conditions and factors that could affect FC levels, such as immunodeficiency, gastrointestinal disease, and medication use.

Main Results:

A significant negative correlation was observed between age and FC levels (Spearman's rho = -0.603, P<0.01).
The median FC level was 77.0 mcg/g (IQR 246).
No significant influence was found for sex, gestational age, birth weight, delivery type, feeding type, or anthropometric data on FC levels.

Conclusions:

Normal FC values in healthy children are higher than adult levels and decrease with age.
Current upper limits for FC in pediatric patients may need age-specific reconsideration.
Further research is needed to understand FC variations during infancy.