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Effect of 5-hydroxytryptamine on the rate of cerebrospinal fluid production in rabbit
M Lindvall-Axelsson1, C Mathew, C Nilsson
1Department of Medical Cell Research, University of Lund, Sweden.
Experimental Neurology
|February 1, 1988
Abstract:
Infusion of 5-hydroxytryptamine in mock cerebrospinal fluid of rabbits lowered cerebrospinal fluid production dose-dependently by nearly 30%. The effect was amplified in the presence of the monoamine oxidase inhibitor, nialamide. The 5-hydroxytryptamine-induced inhibition was partly counteracted by ketanserin, and further addition of practolol completely blocked the reduction in cerebrospinal fluid formation, suggesting that both 5-hydroxytryptamine receptors and beta 1-adrenergic receptors were involved in the response mediated by both the secretory epithelium and the vascular bed of the plexus.