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Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A
Eduardo Orrego-González1, Luisa Londoño-Tobón1, José Ardila-González1
1Research Group, Neurosciences (NEUROS), School of Medicine and Health Sciences, Universidad Del Rosario, Bogotá, Colombia.
Evidence-Based Complementary and Alternative Medicine : Ecam
|August 9, 2020
Summary
Cannabinoids show promise in reducing colorectal cancer (CRC) progression by decreasing preneoplastic lesions and tumor volume in animal models. Further research is essential to explore their therapeutic potential in CRC treatment.
Area of Science:
- Oncology
- Pharmacology
- Natural Products
Background:
- Colorectal cancer (CRC) poses a significant global health burden.
- Current chemotherapy for CRC has limitations including severe side effects and potential ineffectiveness.
- Cannabinoids are being investigated for their potential anti-cancer properties and ability to mitigate chemotherapy side effects.
Purpose of the Study:
- To systematically review experimental studies on animal models of CRC.
- To evaluate the efficacy of cannabinoids in reducing preneoplastic lesions (aberrant crypt foci) and neoplastic lesion formation.
- To assess the impact of cannabinoids on tumor volume in CRC models.
Main Methods:
- A systematic, qualitative literature review adhering to PRISMA guidelines.
- Searches conducted in PubMed, Embase, and Scopus databases.
- Utilized MESH terms including "colorectal cancer," "cannabinoids," and specific cannabinoid compounds in animal models.
Main Results:
- Eight in vivo studies were analyzed, utilizing azoxymethane (AOM) and xenograft models.
- Cannabidiol botanical substance (CBD BS) and rimonabant significantly reduced aberrant crypt foci (ACF) by 86% and 75.4%, respectively.
- Cannabigerol, O-1602, and URB-602 effectively reduced tumor volume; mechanisms include apoptosis induction and angiogenesis inhibition.
Conclusions:
- Cannabinoids demonstrate significant potential as antineoplastic agents against CRC in experimental settings.
- Observed reductions in tumor volume and ACF formation highlight their therapeutic promise.
- Further experimental research is necessary to elucidate the pharmacology of cannabinoids in CRC.
