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Published on: August 7, 2017
Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E
Aibibai Aierken1, Bweimaieryemu Yusufu2, Peiru Xu1,3
1Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Insights
Infantile asthma with rickets is linked to lower vitamin D and higher inflammatory markers, including interleukin-1, IL-6, IL-17, and immunoglobulin E. These factors correlate with longer wheezing durations in infants.
Area of Science:
- Pediatrics
- Immunology
- Nutritional Science
Background:
- Asthma is a common respiratory condition in infants.
- Rickets, a bone disease, can coexist with asthma.
- The interplay between vitamin D, inflammation, and immune responses in infantile asthma with rickets requires further investigation.
Purpose of the Study:
- To investigate the correlation between vitamin D, inflammatory factors, and immunoglobulin levels in infants with asthma and rickets.
- To compare these levels between infants with simple asthma and those with both asthma and rickets.
Main Methods:
- A cohort of 60 infants diagnosed with asthma was divided into two groups: 17 with rickets (observation group) and 43 without (control group).
- Serum levels of interleukin-1 (IL-1), IL-6, IL-17, immunoglobulin E, and vitamin D were measured.
- Wheezing duration during asthma attacks was recorded.
Main Results:
- Infants with asthma and rickets exhibited significantly higher levels of IL-1, IL-6, IL-17, and immunoglobulin E compared to the control group.
- Vitamin D levels were significantly lower in the observation group.
- Wheezing duration was longer in infants with asthma and rickets, correlating positively with inflammatory markers and negatively with vitamin D levels.
Conclusions:
- Infantile asthma with rickets is closely associated with low vitamin D levels and elevated inflammatory factors and immunoglobulin E.
- These factors are identified as major risk factors contributing to infantile asthma with rickets and prolonged wheezing.
Abstract:
Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin was investigated. A total of 60 child patients with asthma who met the inclusion criteria and received treatment from January 2016 to October 2017 were collected. Among them, 17 asthmatic infants with rickets were set as observation group, while 43 child patients with simple asthma were regarded as the control group. Venous blood was drawn from the two groups of subjects after admission. The levels of interleukin-1 (IL-1), IL-6 and IL-17 in serum were determined by ELISA, vitamin D and immunoglobulin E levels in serum were detected using a fully-automatic biochemical analyzer, and wheezing duration during asthma attack was recorded. IL-1, IL-6, IL-17 and immunoglobulin E levels in serum of observation group were significantly higher than those of the control group (P<0.05). The vitamin D level in the observation group was remarkably lower than that in the control group (P<0.05). Wheezing duration in observation group was evidently longer than that in control group (P<0.05). Moreover, IL-1, IL-6, IL-17 and immunoglobulin E levels in serum were positively related to wheezing duration, but the vitamin D level was negatively associated with wheezing duration. Infantile asthma with rickets is closely correlated with vitamin D, inflammatory factors and immunoglobulin E, which are major risk factors in infantile asthma with rickets.
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