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Etiologic role of Borrelia burgdorferi in morphea: A case report
Florica Șandru1,2, Adelina Popa2, Aida Petca1,3
1'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Abstract:
Morphea is an inflammatory skin disease with self-limited evolution, presenting as localized sclerosis of the skin and/or underlying tissues. The incidence is not exactly known; the disease occurs more frequently in women, and there is no sex prevalence. Pathogenesis of morphea remains still controversial. Several theories exist and the Borrelia burgdorferi infection is not yet elucidated. The aim of this report is to present the main mechanisms involved in the etiophatogenesis of morphea and also the thepapeutic options. A case of a 60-year-old woman is presented, who was referred to the clinic for an erythematous-violaceus, asymptomatic eruption, located on the trunk and legs, for appoximately 2 months. The patient's medical history revealed an infection with Borrelia 1 year previously. After diagnosis of morphea was established, and with systemic therapy (corticosteroids and methotrexate), the evolution was favorable.
Insights
Morphea is a skin condition causing localized hardening. This report discusses its causes and treatments, highlighting a case study of a woman with a Borrelia infection who responded well to therapy.
Area of Science:
- Dermatology
- Immunology
- Infectious Diseases
Background:
- Morphea is an inflammatory skin condition characterized by localized sclerotic lesions.
- Its exact incidence and pathogenesis, including the role of Borrelia burgdorferi infection, remain under investigation.
- The condition affects women more frequently, though no definitive sex prevalence is established.
Purpose of the Study:
- To elucidate the etiological mechanisms of morphea.
- To present current therapeutic strategies for morphea.
- To report a clinical case illustrating morphea management.
Main Methods:
- Literature review on morphea pathogenesis and treatment.
- Presentation of a clinical case of a 60-year-old woman with morphea.
- Review of patient's medical history, including a prior Borrelia infection.
Main Results:
- The patient presented with a 2-month history of asymptomatic, erythematous-violaceous eruption on the trunk and legs.
- A history of Borrelia infection one year prior to presentation was noted.
- Favorable evolution of morphea was observed following systemic therapy.
Conclusions:
- Morphea pathogenesis involves complex mechanisms, with the role of Borrelia infection requiring further study.
- Systemic corticosteroid and methotrexate therapy can be effective in managing morphea.
- Early diagnosis and appropriate treatment are crucial for favorable patient outcomes.
