Historical retrospective of the SRC oncogene and new perspectives (Review)

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• The SRC proto-oncogene, discovered in Rous sarcoma virus (RSV), is crucial for normal cell functions like development, proliferation, and survival.
• Dysregulation of SRC is a hallmark of cancer, driving initiation and progression.
• SRC's role in cancer makes it a significant target for anti-cancer therapies.

Purpose of the Study:

• To provide a historical overview of SRC research, highlighting key milestones.
• To investigate SRC's regulatory mechanisms and mediating molecules for therapeutic and diagnostic applications.
• To discuss current therapeutic strategies targeting SRC in clinical settings.

Main Methods:

• Literature review of SRC research history.
• Analysis of proposed regulatory mechanisms and signaling pathways.
• Discussion of existing and potential therapeutic approaches.

Main Results:

• SRC is a critical regulator of cell functions, with its dysregulation linked to oncogenesis.
• Identification of potential therapeutic targets and prognostic/diagnostic tools based on SRC's action.
• Overview of clinical trials and therapeutic strategies involving SRC.

Conclusions:

• SRC's dual role in normal cell function and cancer progression underscores its importance.
• Further understanding of SRC mechanisms can lead to novel anti-cancer therapies.
• Targeting SRC offers promising avenues for cancer treatment and management.