Related Experiment Video

Updated: Dec 12, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.9K

Biogenesis, Features, Functions, and Disease Relationships of a Specific Circular RNA: CDR1as

Ziyuan Guo1, Qidong Cao1, Zhuo Zhao1

  • 1Department of Cardiovascular Internal Medicine, the Second Hospital of Jilin University, Changchun, China.

Aging and Disease
|August 9, 2020
PubMed

Insights

Circular RNAs (CircRNAs) like CDR1as play roles in diseases by sponging microRNAs. This review analyzes conflicting CDR1as research to clarify its diagnostic and therapeutic potential in conditions such as cancer and diabetes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The cerebellar degeneration-related protein 1 antisense RNA (CDR1as), a circular RNA (CircRNA), is conserved and widely expressed in mammalian brains and tissues.
  • CDR1as functions as a microRNA (miR) sponge, implicating it in various disease processes.
  • Existing research on CDR1as presents inconsistencies and unclear conclusions regarding its role in diseases.

Purpose of the Study:

  • To systematically review and analyze recent studies on CDR1as.
  • To elucidate accurate conclusions regarding the biogenesis, features, functions, and disease associations of CDR1as.
  • To clarify the diagnostic and therapeutic potential of CDR1as in diseases like cancer and diabetes.

Main Methods:

  • Comprehensive literature search for studies on CDR1as.
  • Critical analysis of experimental results and reported conclusions.
  • Synthesis of findings to identify consistent patterns and discrepancies.

Main Results:

  • CDR1as is extensively expressed and conserved across mammalian species.
  • Evidence suggests CDR1as acts as a significant microRNA sponge in cellular processes.
  • Inconsistencies in current literature highlight the need for further rigorous investigation.

Conclusions:

  • Further research on CDR1as is crucial for understanding its precise role in diseases.
  • Clarifying CDR1as functions could lead to novel diagnostic markers and therapeutic strategies for cancer, diabetes, and other conditions.
  • A unified understanding of CDR1as is needed to harness its clinical potential.

Keywords:
CDR1asbiogenesisfunctionsmiR-7sponge

More Related Videos

Identification of Circular RNAs using RNA Sequencing08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.6K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.6K

Related Concept Videos

piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.4K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.1K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
27.5K
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.6K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.1K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
48.9K