Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What impacts care complexity in RA? An integrative review of complexity domains and associated patient and health system outcomes.

The Journal of rheumatology·2026

Same author

Predictors of relapse, early escalation and 1-Year use of glucocorticoids in new-onset polymyalgia rheumatica: A prospective cohort study.

Seminars in arthritis and rheumatism·2026

Same author

Biological tapering is cost-effective in patients with inflammatory arthritis in the biosimilar era: secondary analyses on the randomised BIODOPT trial.

EULAR rheumatology open·2026

Same author

Examining emergency department utilisation in people with Crystal Arthropathies: a 10-year analysis of visits in a publicly funded universal healthcare system.

EULAR rheumatology open·2026

Same author

A single site, multi-operator precision study for second-generation HR-pQCT.

JBMR plus·2026

Same author

Investigating the utility of HR-pQCT for the assessment of joint space and bone mineral density in hand osteoarthritis.

Osteoarthritis imaging·2026

Search research articles

Related Experiment Video

Updated: Dec 12, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease.

Rasmus Klose-Jensen^1,2, Justin J Tse^3,4, Kresten Krarup Keller⁵

¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.

Frontiers in Medicine

|August 9, 2020

Summary

High-resolution peripheral quantitative computed tomography (HR-pQCT) offers sensitive bone assessment in inflammatory arthritis, aiding disease monitoring and treatment response evaluation. This advanced imaging technique helps detect subtle bone changes, improving patient management and outcomes.

Keywords:

HR-pQCT (high-resolution peripheral quantitative computed tomography)arthritis bone microstructure bone mineral density erosions joint space osteophytes

More Related Videos

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Related Experiment Videos

Last Updated: Dec 12, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Area of Science:

Orthopedics and Rheumatology
Medical Imaging
Bone Biology

Background:

Inflammatory arthritis impacts bone health, necessitating sensitive monitoring tools.
High-resolution peripheral quantitative computed tomography (HR-pQCT) provides detailed 3D bone analysis.
HR-pQCT quantifies bone density, microstructure, and changes like erosions and osteophytes.

Approach:

A systematic review of 69 publications using HR-pQCT for metacarpophalangeal and wrist joints in arthritis.
Evaluation of techniques for identifying and quantifying bone erosions, a key marker of early inflammatory arthritis.
Analysis of HR-pQCT's utility in monitoring disease progression and treatment response over time.

Key Points:

HR-pQCT detects subtle bone changes, including early erosions, with high sensitivity and reliability.
Quantitative erosion volume changes can be monitored longitudinally, showing progression or repair.
HR-pQCT aids in differentiating inflammatory arthritis from healthy controls and may guide treatment decisions.

Conclusions:

HR-pQCT is a valuable research tool for assessing inflammatory arthritis, offering sensitive monitoring of bone changes.
Further development is needed to address challenges like motion artifacts and expand tissue analysis capabilities.
Dissemination of HR-pQCT analysis methods is crucial for broader clinical and research application.