Related Experiment Video

Updated: Jul 11, 2026

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.3K

COVID-19 in 7780 pediatric patients: A systematic review

Ansel Hoang1, Kevin Chorath1, Axel Moreira2

  • 1Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.

Eclinicalmedicine
|August 9, 2020
PubMed

Insights

This review found that most children with COVID-19 (coronavirus disease 2019) have an excellent prognosis, with a low mortality rate. Further research is needed to identify children at risk for severe outcomes.

Area of Science:

  • Pediatric infectious diseases
  • Respiratory viral infections
  • Global health

Background:

  • Limited data exists on the clinical presentation of COVID-19 in pediatric populations.
  • Characterizing symptoms, laboratory findings, and imaging in children is crucial for effective management.

Purpose of the Study:

  • To systematically review and synthesize the clinical characteristics, diagnostic findings, and outcomes of COVID-19 in children.
  • To provide a comprehensive overview of the pediatric COVID-19 landscape.

Main Methods:

  • A systematic literature search was conducted across major medical databases following PRISMA guidelines.
  • Included were peer-reviewed studies reporting clinical, imaging, and laboratory data for confirmed pediatric COVID-19 cases.
  • Risk of bias was assessed using the National Institutes of Health quality assessment tool.

Main Results:

  • 131 studies from 26 countries included 7780 pediatric patients; 19.3% were asymptomatic.
  • Fever and cough were common symptoms; chest imaging revealed patchy lesions and ground-glass opacities.
  • Underlying conditions were noted in a subset of patients; coinfections and abnormal lab markers were observed. Mortality was low (0.09%), with 11 cases of multisystem inflammatory syndrome.

Conclusions:

  • Children with COVID-19 generally exhibit an excellent prognosis.
  • Longitudinal studies are necessary to identify risk factors for severe disease, inflammation, and multiorgan failure in pediatric patients.
Abstract

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.8K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

998

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...