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Induced pluripotent stem cells as a platform to understand patient-specific responses to opioids and anaesthetics

Detlef Obal1,2,3, Joseph C Wu1,4,5

  • 1Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.

British Journal of Pharmacology
|August 9, 2020
PubMed

Recent advances in human induced pluripotent stem cell (iPSC) technology may provide unprecedented opportunities to study patient-specific responses to anaesthetics and opioids. In this review, we will (1) examine the advantages and limitations of iPSC technology, (2) summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular system and central nervous system (CNS), and (3) describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies with reduced or minimal detrimental cardiovascular effects.

Keywords:
anaestheticsbraincardiomyocyteiPSCketamineopioidspropofol

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