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Ginseng Omics for Ginsenoside Biosynthesis.

Xianmei Yin¹, Haoyu Hu², Xiaofeng Shen²

¹Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Distinctive Chinese Medicine Resources in Southwest China, Chengdu 611137, China.

Current Pharmaceutical Biotechnology

|August 10, 2020

Summary

This summary is machine-generated.

Ginseng

Keywords:

Panax ginseng genomics ginsenoside metabolomics.proteomics transcriptomics

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Area of Science:

Plant Biochemistry
Genomics
Metabolomics

Background:

Ginseng, a revered traditional medicine, contains bioactive ginsenosides.
The intricate nature of ginsenosides has historically impeded research and development.
Understanding ginsenoside biosynthesis is crucial for ginseng's cultivation and clinical applications.

Purpose of the Study:

To review advancements in ginseng omics research.
To elucidate the ginsenoside biosynthesis pathway using modern biological tools.
To discuss regulatory gene families involved in ginsenoside production.

Main Methods:

Utilizing omics technologies (genomics, transcriptomics, proteomics).
Applying bioinformatics and computational biology tools.
Analyzing the organization and expression of the ginsenoside biosynthesis pathway.

Main Results:

Detailed illustration of the complete ginsenoside biosynthesis pathway.
Characterization of the upstream mevalonate (MVA) pathway.
Explanation of precursor cyclization and glycosylation processes.

Conclusions:

Omics and bioinformatics tools are revolutionizing ginseng research.
The elucidated pathway provides a foundation for future ginseng studies.
Identification of regulatory factors offers targets for pathway engineering.