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Role of Opioidergic System in Regulating Depression Pathophysiology

George Anderson1, Michael Maes2

  • 1CRC Scotland & London, Eccleston Square, London, United Kingdom.

Current Pharmaceutical Design
|August 10, 2020
PubMed
Abstract

Insights

The endogenous opioidergic system plays a key role in major depressive disorder (MDD) pathophysiology. Understanding its interactions offers new therapeutic targets for MDD treatment.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • Major Depressive Disorder (MDD) requires better understanding of its biological basis for targeted treatments.
  • Emerging evidence highlights the involvement of the endogenous opioidergic system in MDD.
  • This review explores the role of the endogenous opioidergic system in MDD pathophysiology and its heterogeneity.

Purpose of the Study:

  • To review the roles and physiological interactions of the endogenous opioidergic system in MDD.
  • To explore the connection between the endogenous opioidergic system and MDD pathophysiology.
  • To identify the endogenous opioidergic system as a potential therapeutic target for MDD.

Main Methods:

  • Literature review of articles on MDD pathophysiology.
  • Literature review of articles on the endogenous opioidergic system.
  • Literature review of articles on mitochondrial function.

Main Results:

  • The endogenous opioidergic system is linked to MDD pathophysiology, affecting gut microbiome, permeability, circadian rhythms, and brain function.
  • A reduced μ-/κ-opioid receptor ratio is a key factor in mood changes in MDD.
  • These effects impact neurons, glia, and immune cells.

Conclusions:

  • The endogenous opioidergic system is integral to MDD pathophysiology.
  • This system presents a viable target for developing novel MDD treatments.
  • It serves as a focal point for integrating a broader understanding of MDD pathophysiology.
Keywords:
DepressionLPSamygdalaceramidecircadian rhythmendogenous opioidsgut dysbiosisinflammationmelatoninmitochondria

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