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CDKN2B-AS1: An Indispensable Long Non-coding RNA in Multiple Diseases

Chaoying Song1, Yuying Qi1, Jiali Zhang1

  • 1Department of Biochemistry and Molecular Biology, College of Medical Science, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|August 10, 2020
PubMed
Abstract

Insights

Long non-coding RNA CDKN2B-AS1 (CDKN2B-AS1) plays a role in numerous diseases. This review summarizes its functions and potential as a therapeutic target or biomarker.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in human diseases.
  • The lncRNA CDKN2B-AS1 has demonstrated involvement in various pathophysiological processes.
  • Understanding CDKN2B-AS1's function is crucial for disease research.

Purpose of the Study:

  • To investigate the molecular mechanisms of CDKN2B-AS1.
  • To explore the clinical significance of CDKN2B-AS1 in diverse diseases.
  • To evaluate CDKN2B-AS1's potential as a therapeutic and prognostic target.

Main Methods:

  • Systematic literature search of PubMed, Wiley Online Library, and ScienceDirect.
  • Analysis of existing studies on CDKN2B-AS1's biological functions and mechanisms.
  • Review of CDKN2B-AS1 expression and its correlation with disease progression.

Main Results:

  • CDKN2B-AS1 is aberrantly expressed in multiple cancers, including liver, gastric, lung, and breast cancers.
  • It influences tumor cell proliferation, migration, invasion, and apoptosis.
  • CDKN2B-AS1 is implicated in non-malignant conditions like fibrosis, diabetes, and cardiovascular diseases, affecting metabolism and inflammation.

Conclusions:

  • CDKN2B-AS1 exhibits significant roles in both malignant and non-malignant diseases.
  • Its dysregulation highlights its involvement in critical biological processes.
  • CDKN2B-AS1 represents a promising biomarker for prognosis and a potential therapeutic target.
Keywords:
CDKN2B-AS1LncRNAsmalignanciesnon-malignant diseasesprognosis biomarkertumor

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