Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.5K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.5K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

788
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
788
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

678
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
678
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

2.9K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
2.9K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.7K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.7K
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions01:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

773
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
773

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proprioceptive synaptic dysfunction is a key feature in mice and humans with spinal muscular atrophy.

Brain : a journal of neurology·2025
Same author

Biallelic Loss-of-Function Variants in <i>BICD1</i> Are Associated with Peripheral Neuropathy and Hearing Loss.

International journal of molecular sciences·2023
Same author

Lack of effect on ambulation of dalfampridine-ER (4-AP) treatment in adult SMA patients.

Neuromuscular disorders : NMD·2020
Same author

Peripheral neuropathy symptoms in wild type transthyretin amyloidosis.

Journal of the peripheral nervous system : JPNS·2020
Same author

Update on Chemotherapy-Induced Peripheral Neuropathy.

Current neurology and neuroscience reports·2017
Same author

Syncope: Case Studies.

Neurologic clinics·2016

Related Experiment Video

Updated: Dec 12, 2025

Author Spotlight: Advancing Labor Management Through Electromyometrial Imaging for Understanding Uterine Contractions
08:07

Author Spotlight: Advancing Labor Management Through Electromyometrial Imaging for Understanding Uterine Contractions

Published on: May 26, 2023

1.7K

Neuromuscular disorders in pregnancy.

Louis H Weimer1

  • 1Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.

Handbook of Clinical Neurology
|August 10, 2020
PubMed
Summary
This summary is machine-generated.

Pregnancy can trigger or worsen neuromuscular disorders, posing risks during labor and delivery. Careful management and treatment decisions are crucial for maternal and fetal well-being.

Keywords:
Bell palsyBrachial neuritisCarpal tunnel syndromeMeralgia parestheticaMyasthenia gravisMyositisPlasmapheresisPolyneuropathy

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.2K
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.5K

Related Experiment Videos

Last Updated: Dec 12, 2025

Author Spotlight: Advancing Labor Management Through Electromyometrial Imaging for Understanding Uterine Contractions
08:07

Author Spotlight: Advancing Labor Management Through Electromyometrial Imaging for Understanding Uterine Contractions

Published on: May 26, 2023

1.7K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.2K
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.5K

Area of Science:

  • Neurology
  • Obstetrics
  • Genetics

Background:

  • Neuromuscular disorders frequently coexist with pregnancy, sometimes emerging during gestation.
  • Existing literature primarily comprises case reports and retrospective analyses.

Purpose of the Study:

  • To review pregnancy-induced changes in neuromuscular disorder course and severity.
  • To outline challenges in labor, delivery, and anesthesia for pregnant individuals with neuromuscular conditions.
  • To discuss therapeutic considerations and risks for affected pregnancies.

Main Methods:

  • Comprehensive literature review of neuromuscular disorders in pregnancy.
  • Analysis of case reports, series, and clinical experience.
  • Categorization of disorders including autoimmune, hereditary, and mechanical types.

Main Results:

  • Pregnancy can unmask latent hereditary neuromuscular conditions.
  • Skeletal muscle disorders present unique labor and delivery challenges.
  • Therapeutic decisions are complicated by potential fetal risks, necessitating careful risk-benefit assessment.

Conclusions:

  • Anticipating and managing neuromuscular disorders during pregnancy is essential.
  • Specialized care is required for labor, delivery, and anesthesia.
  • Treatment strategies must balance maternal health with fetal safety, considering options like pre-pregnancy intervention.