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Updated: Dec 12, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Preeclampsia, eclampsia, and posterior reversible encephalopathy syndrome
Sadhana Murali1, Kristin Miller2, Mollie McDermott1
1Department of Neurology, University of Michigan Stroke Program, Ann Arbor, MI, United States.
Preeclampsia and eclampsia are pregnancy disorders causing hypertension and organ dysfunction. Neurologic symptoms, seizures, and brain abnormalities can occur, suggesting a shared underlying cause or spectrum.
Area of Science:
- Obstetrics and Gynecology
- Neurology
- Maternal-Fetal Medicine
Background:
- Preeclampsia is a pregnancy disorder with gestational hypertension and end-organ dysfunction.
- Eclampsia is defined by seizures in preeclamptic patients.
- Neurologic symptoms beyond seizures can occur in preeclampsia.
Purpose of the Study:
- To review neurologic complications in preeclampsia and eclampsia.
- To explore pathophysiology, clinical presentation, and diagnostic findings.
- To discuss the prognosis of these neurologic complications.
Main Methods:
- Literature review of preeclampsia and eclampsia.
- Analysis of clinical presentations and diagnostic findings.
- Review of radiographic abnormalities and pathophysiology.
Main Results:
- Preeclampsia and eclampsia share neurologic manifestations.
- Radiographic findings can resemble posterior reversible encephalopathy syndrome.
- A common pathophysiology or spectrum of disorders is suggested.
Conclusions:
- Neurologic complications are significant in preeclampsia and eclampsia.
- Understanding these complications aids diagnosis and management.
- Further research into the shared pathophysiology is warranted.
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