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Updated: Dec 12, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Epstein-Barr virus is a promoter of lymphoma cell metastasis
Shinji Shimada1, Hideya Kawasaki2, Yong Diao1
1School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, China.
Abstract:
It is well-known that Epstein-Barr virus (EBV) is the promoter of cell tumourigenesis. We found that EBV is also a promoter of lymphoma cell dissemination, because we found the typical morphopathological phenomenon of cell adhesion, which confirmed that the adhesion of tumour cells was higher than that of normal cells. We also observed that tumour cells disrupted the dynamic pathological changes of vascular endothelial cells, and this made it clear that the rate of tumour cell metastasis was directly proportional to the degree of EBV infection. Furthermore, when we discovered exosomes, it was considered that this was associated with cancer stem cells, suggesting the formation of a microenvironment before tumour cell metastasis. In addition, competitive inhibition was found in cell adhesion, indicating the breakthrough point of preventing tumour cell metastasis, which has clinical reference value for tumour immunotherapy.
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