A microfluidic computational fluid dynamics model for cellular interaction studies of sickle cell disease vaso-occlusions
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Published on: June 22, 2012
Ian P Blakely1, Renita E Horton2
1Agricultural and Biological Engineering, College of Arts and Life Sciences, James Worth Bagley College of Engineering, Mississippi State University, United States of America.
Individuals with sickle cell disease are plagued with vaso-occlusions, chronic blockages within the vasculature. Several factors including stiffer sickle red blood cells and increased cell aggregation contribute to vaso-occlusion formation; however much remains to be understood. We present a computational fluid dynamics blood flow simulation within a microfluidic platform using the Carreau model and Murray's law. Vaso-occlusions form preferentially near bifurcations within 60 s in the sickle cell disease simulation. Velocity profiles and shear rates align with clinical and experimental reports. We assert that results from this study can be utilized to inform experimental investigations and microfluidic system design decisions.
Individuals with sickle cell disease are plagued with vaso-occlusions, chronic blockages within the vasculature. Several factors including stiffer sickle red blood cells and increased cell aggregation contribute to vaso-occlusion formation; however much remains to be understood. We present a computational fluid dynamics blood flow simulation within a microfluidic platform using the Carreau model and Murray's law. Vaso-occlusions form preferentially near bifurcations within 60 s in the sickle cell disease simulation. Velocity profiles and shear rates align with clinical and experimental reports. We assert that results from this study can be utilized to inform experimental investigations and microfluidic system design decisions.
