Comprehensive methodology for commissioning modern 3D-image-based treatment planning systems for high dose rate...

Correct commissioning of treatment planning systems (TPSs) is important for reducing treatment failure events. There is currently no comprehensive and robust methodology available for TPS commissioning in modern brachytherapy. This review aimed to develop a comprehensive template for commissioning modern 3D-image-based brachytherapy TPSs for high dose rate (HDR) gynaecological applications.

The literature relevant to TPS commissioning, including both external beam radiation therapy (EBRT) and brachytherapy, as well as guidelines by the International Atomic Energy Agency (IAEA), the American Association of Physicists in Medicine (AAPM), and the European Society for Radiotherapy and Oncology (ESTRO) were searched, studied and appraised. The applied relevant EBRT TPS commissioning tests were applied to brachytherapy. The developed template aimed to cover all dosimetric and non-dosimetric issues.

The essential commissioning items could be categorized into six parts: geometry, dose calculation, plan evaluation tools, plan optimization, TPS output, and end-to-end verification. The final template consists of 43 items. This paper presents the purpose and role of each test, as well as tolerance limits, to facilitate the use of the template.

The information and recommendations available in a collection of publications over many years have been reviewed in order to develop a comprehensive template for commissioning complex modern 3D-image-based brachytherapy TPSs for HDR gynaecological applications. The up-to-date and concise information contained in the template can aid brachytherapy physicists during TPS commissioning as well as devising a regular quality assurance program and allocation of time and resources.