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Related Experiment Video

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Stability of dosomics features extraction on grid resolution and algorithm for radiotherapy dose calculation.

L Placidi1, J Lenkowicz2, D Cusumano1

  • 1Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Roma, Italy; Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|August 10, 2020
PubMed
Summary

Dosomics texture analysis is reproducible for radiotherapy dose distributions. Feature stability varies by region, with the RING structure being most stable, highlighting the need to report calculation parameters.

Keywords:
Dose distribution texture analysisDosomicsFeatures repeatabilityFeatures stability

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Area of Science:

  • Medical Physics
  • Radiotherapy
  • Image Analysis

Background:

  • Dosomics offers high-resolution radiotherapy dose analysis beyond traditional methods.
  • Investigating dosomics feature stability is crucial for clinical application.

Purpose of the Study:

  • To assess the stability and reproducibility of dosomics features.
  • To evaluate the impact of grid resolution and dose calculation algorithms on dosomics features.

Main Methods:

  • Generated 144 3D dose distributions by varying grid resolution and dose calculation algorithms.
  • Extracted 214 dosomics features from PTV, OARs, and RING structures.
  • Analyzed feature reproducibility (Rfe) and stability (Sfe) using ICC and coefficient of variation.

Main Results:

  • Dosomics feature extraction demonstrated high reproducibility (ICC > 0.99).
  • Feature stability varied by region: most stable in the RING, higher Sfe in OARs (GLSZM) and PTV (GLCM).

Conclusions:

  • Dosomics feature extraction is stable and reproducible for clinical dose distributions.
  • Reporting grid resolution and dose calculation algorithm is essential for dosomics studies.