Mechanical regulation of cell size, fate, and behavior during asymmetric cell division

Asymmetric cell division (ACD) is an evolutionary conserved mechanism used by prokaryotes and eukaryotes alike to generate cell diversity. ACD can be manifested in biased segregation of macromolecules or differential partitioning of cell organelles. Cells are also constantly subject to extrinsic or intrinsic mechanical forces, influencing cell behavior and fate. During ACD, cell intrinsic forces generated through the spatiotemporal regulation of the actomyosin cytoskeleton can influence sibling cell size. External mechanical stresses are further translated by transcriptional coactivators or mechanically gated ion channels. Here, we will discuss recent literature, exploring how mechanical cues influence various aspects of ACD and stem cell behavior, and how these mechanical cues contribute to cell fate decisions.