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A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
10:31

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion

Published on: September 25, 2014

13.8K

Evaluation of current post-concussion protocols.

Kristin Kim1, Ronny Priefer1

  • 1Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, United States.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 10, 2020
PubMed
Summary
This summary is machine-generated.

Treatments for post-concussion syndrome (PCS) lack consistent evidence. This review analyzes common pharmaceutical and non-pharmaceutical interventions for mild traumatic brain injury (mTBI) symptom management, highlighting their variable efficacy.

Keywords:
ConcussionElectroencephalogram neurofeedbackMild traumatic brain injuryOsteopathic medicine and physical therapyPost-concussive syndromeVitamin C

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Area of Science:

  • Neuroscience
  • Sports Medicine
  • Pharmacology

Background:

  • Mild traumatic brain injury (mTBI) and post-concussion syndrome (PCS) present significant health challenges due to limited evidence-based treatments.
  • Current management strategies, including physical therapy, analgesics, antidepressants, and nutraceuticals, yield inconsistent outcomes, with some patients experiencing symptom exacerbation.

Purpose of the Study:

  • To evaluate the efficacy of commonly utilized pharmaceutical and non-pharmaceutical treatment protocols for post-concussion syndrome (PCS).
  • To analyze the strengths and weaknesses of various agents in managing symptoms following mild traumatic brain injury (mTBI).

Main Methods:

  • Review of existing literature on pharmaceutical and non-pharmaceutical interventions for PCS.
  • Analysis of treatment protocols, considering their application in the post-injury interval and patient baseline characteristics.
  • Evaluation of agents such as fluoxetine and antioxidants like ascorbic acid for their impact on mTBI-related biochemical changes, including reactive oxygen species (ROS).

Main Results:

  • Inconsistent outcomes observed across various treatment modalities for PCS.
  • Fluoxetine shows potential for symptom management in some patients, but conclusive data is lacking.
  • Antioxidants, while intended to counteract oxidative stress (ROS), may paradoxically increase ROS levels.

Conclusions:

  • There is a critical need for standardized treatment protocols for post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI).
  • Further research is required to establish definitive evidence-based treatments, considering the complex biochemical changes and variable patient responses.
  • Comparative analysis suggests potential differential benefits among treatments, necessitating careful consideration of individual patient needs and injury characteristics.