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Marine compounds targeting the PI3K/Akt signaling pathway in cancer therapy

Jiaen Wei1, Zhanping Gou2, Ying Wen2

  • 1Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong 523808, China; Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University, Research Platform Service Management Center, Guangdong Medical University, Dongguan, Guangdong 523808, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 10, 2020
PubMed

Insights

Marine compounds show promise for cancer treatment by targeting the PI3K/Akt pathway. This review explores their potential antitumor effects and mechanisms for developing new cancer therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Marine Biotechnology

Background:

  • Cancer is a complex disease characterized by uncontrolled cell proliferation, invasion, and metastasis.
  • The phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is crucial in cancer development and progression.
  • Current cancer treatments, primarily chemotherapy, are limited by drug efficacy and resistance.

Purpose of the Study:

  • To review marine-derived compounds that target the PI3K/Akt signaling pathway for cancer treatment.
  • To elucidate the mechanisms of action of these marine compounds against cancer.
  • To highlight the therapeutic potential of marine natural products in oncology.

Main Methods:

  • Literature review of scientific publications on marine compounds and the PI3K/Akt pathway.
  • Analysis of studies investigating the antitumor effects of marine-derived substances.
  • Compilation of data on marine compounds' mechanisms, including antiproliferative, apoptotic, and cell cycle regulatory activities.

Main Results:

  • Numerous marine organisms yield compounds with significant anticancer properties.
  • Many marine compounds modulate the PI3K/Akt pathway, inhibiting cancer cell proliferation and survival.
  • Evidence suggests marine-derived agents can induce apoptosis and cell cycle arrest in cancer cells.

Conclusions:

  • Marine compounds targeting the PI3K/Akt pathway represent a promising avenue for novel cancer therapeutics.
  • Further research into the mechanisms and clinical applications of these compounds is warranted.
  • The development of marine drugs offers a new direction for effective cancer prevention and treatment.
Keywords:
AnticancerMarine compoundsPI3K/Akt

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