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Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with

K Dhanalakshmi1, Aishwarya Venkataraman2, S Balasubramanian1

  • 1Department of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.

Indian Pediatrics
|August 10, 2020
PubMed

Insights

Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS) in children presents with diverse symptoms including fever and multi-organ involvement. This study found no deaths among affected children, indicating potential for good outcomes with treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Cardiology

Background:

  • Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS) is a serious condition affecting children.
  • Understanding PIMS-TS is crucial for timely diagnosis and management.

Purpose of the Study:

  • To describe the demographic, clinical, and laboratory findings of children with PIMS-TS.
  • To report on the treatment and outcomes for children diagnosed with PIMS-TS.

Main Methods:

  • Analysis of clinical and laboratory data from children meeting the PIMS-TS case definition.
  • Data collected over an 8-week period from May 4, 2020, to July 8, 2020.

Main Results:

  • Nineteen children with a median age of 6 years were identified with PIMS-TS.
  • Common symptoms included fever, multi-organ involvement (79%), mucocutaneous (74%), cardiovascular (63%), and gastrointestinal (42%) symptoms.
  • All patients had elevated C-reactive protein; 63% required intensive care, but no deaths occurred.

Conclusions:

  • PIMS-TS presents with a broad spectrum of clinical manifestations.
  • This series showed fewer coronary artery abnormalities and low RT-PCR positivity, but high SARS-CoV-2 antibody presence.
Abstract

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