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Shedding Light on COVID-19: ADAM17 the Missing Link?

Brittany Schreiber1,2, Ankit Patel1, Ashish Verma1

  • 1Renal Division, Brigham and Women's Hospital, Boston, MA; and.

American Journal of Therapeutics
|August 10, 2020
PubMed

Insights

Investigating A disintegrin and metalloproteinase 17 (ADAM17) in COVID-19 reveals its potential role in the inflammatory response and immune evasion. Understanding ADAM17

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global health crisis.
  • A disintegrin and metalloproteinase 17 (ADAM17) is an ectodomain sheddase involved in ACE2 modulation, inflammation, and immunosurveillance.

Purpose of the Study:

  • To explore the role and regulation of ADAM17 in COVID-19 immunopathogenesis.
  • To identify potential therapeutic targets related to ADAM17 in COVID-19.

Main Methods:

  • Systematic literature search of MEDLINE, Embase, Google Scholar, medRxiv, and bioRxiv.
  • Inclusion of articles on ADAM17 and coronaviruses (SARS-CoV-1, SARS-CoV-2) published from 2005 to 2020.
  • Screening of reference lists and cross-referencing.

Main Results:

  • SARS-CoV-2 infection may increase ADAM17 activity, promoting inflammation and impairing viral clearance.
  • Severe COVID-19 lung injury is linked to elevated TNF-α and IL-6, T-cell dysfunction, and hypercoagulability.
  • Clinical manifestations of severe COVID-19 align with ADAM17-mediated pathway dysregulation.

Conclusions:

  • ADAM17 plays a significant role in the immunopathogenesis of COVID-19.
  • Elucidating ADAM17's function can reveal new molecular targets for drug development and repurposing in COVID-19 treatment.
Abstract

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