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Effect of butylphthalide on new cerebral microbleeds in patients with acute ischemic stroke
Yunlong Ding1, Zhiqun Gu1, Tingting Zhai1
1Department of Neurology, Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University, Jiangsu, China.
Background:
To evaluate the effect of dl-3-N-butylphthalide (NBP) on new cerebral microbleeds (CMBs) in patients with acute ischemic stroke (AIS).
Methods:
We will prospectively enroll patients with AIS admitted to the stroke center of Jingjiang People's Hospital. Qualified participants will be randomly assigned to either the NBP group (NBP injection) or the control group (NBP injection placebo) in a ratio of 1:1. Patients will complete the brain magnetic resonance imaging within 48 hours and 14 days after stroke onset to observe the CMBs through susceptibility weighted imaging, and evaluate whether the use of NBP will affect the new CMBs in AIS patients. SPSS 20.0 will be used for statistical analyses.
Result:
We will provide practical and targeted results assessing the safety of NBP for AIS patients, to provide reference for clinical use of NBP.
Conclusion:
The stronger evidence about the effect of NBP on new CMBs in AIS patients will be provided for clinicians.
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