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Updated: Dec 12, 2025
06:52
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
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Therapeutic modulation of inflammasome pathways
Dhruv Chauhan1, Lieselotte Vande Walle2, Mohamed Lamkanfi2
1Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.
Immunological Reviews
|August 10, 2020
Summary
Inflammasomes are key immune sensors. Dysregulated inflammasome activation drives disease, prompting interest in novel therapeutic strategies targeting these pathways.
Area of Science:
- Immunology
- Molecular Biology
- Cellular Biology
Background:
- Inflammasomes are multiprotein complexes sensing pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs).
- They orchestrate host defense via interleukin (IL)-1β and IL-18 maturation and gasdermin D (GSDMD)-mediated pyroptosis.
- Tight regulation of inflammasome activation is crucial, as dysregulation contributes to inflammatory, metabolic, and oncogenic diseases.
Purpose of the Study:
- To review the critical role of inflammasomes in host defense and disease pathogenesis.
- To highlight the regulatory mechanisms governing inflammasome activation.
- To discuss the emerging therapeutic potential of targeting inflammasome pathways.
Main Methods:
- Literature review of inflammasome biology and clinical relevance.
- Analysis of regulatory checkpoints in inflammasome activation.
- Evaluation of therapeutic strategies targeting inflammasomes.
Main Results:
- Inflammasomes are essential for immunity but implicated in various pathologies when dysregulated.
- Transcriptional and post-translational controls ensure proper inflammasome function.
- Aberrant inflammasome activity links to autoinflammatory, autoimmune, metabolic, and malignant conditions.
Conclusions:
- Inflammasome pathways are critical mediators of innate immunity and inflammation.
- Improper regulation leads to diverse diseases, necessitating therapeutic intervention.
- Targeting inflammasomes offers a promising strategy for treating inflammatory and related disorders.
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