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Trends in Systemic Sclerosis Mortality Over Forty-Eight Years, 1968-2015: A US Population-Based Study.

Eric Y Yen1, Devanshu R Singh2, Ram R Singh3

  • 1University of California David Geffen School of Medicine, Los Angeles.

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PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) mortality increased until 2000, then declined, but remains high relative to other causes. Trends varied significantly by sex and race over 48 years.

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Area of Science:

  • Epidemiology
  • Public Health
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease with significant morbidity and mortality.
  • Understanding long-term mortality trends is crucial for public health initiatives and patient care.

Purpose of the Study:

  • To analyze secular trends in mortality associated with systemic sclerosis (SSc) over a 48-year period.
  • To evaluate SSc mortality rates in relation to all other causes of death.
  • To examine disparities in SSc mortality by sex and race.

Main Methods:

  • Utilized national mortality data (1968-2015) from CDC WONDER and US Census Bureau population data.
  • Calculated age-standardized mortality rates (ASMR) for SSc and non-SSc causes.
  • Employed joinpoint regression to assess mortality trends overall, by sex, and by race.

Main Results:

  • SSc ASMR increased from 1968 to 2000, then decreased annually from 2001 to 2015.
  • Non-SSc ASMR consistently decreased throughout the study period.
  • Women and Black individuals exhibited higher SSc ASMRs and SSc-to-non-SSc ASMR ratios compared to men and White individuals, respectively.

Conclusions:

  • Systemic sclerosis mortality showed an initial rise followed by a significant decline, yet its relative impact remains substantial.
  • Mortality trends and disparities in systemic sclerosis have evolved differently across sex and racial groups over the past four decades.