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Updated information on new coronavirus disease 2019 occurrence, drugs, and prediction of a potential receptor

Forouzan Khodaei1,2,3, Anam Ahsan3, Mostafa Chamanifard4

  • 1Department of Bioinformatics, College of Life Sciences, Shanxi Agricultural University, Taigu, China.

Journal of Biochemical and Molecular Toxicology
|August 10, 2020
PubMed

Insights

This review explains how the novel coronavirus (COVID-19) infects cells by binding to angiotensin-converting enzyme 2. It details the resulting oxidative stress and immune overactivation, suggesting treatment strategies.

Area of Science:

  • Virology
  • Immunology
  • Pathophysiology

Background:

  • The novel coronavirus (COVID-19) emerged in Wuhan, China, in late 2019.
  • COVID-19 presents with a spectrum of symptoms, from mild cold-like illness to severe pneumonia.
  • The virus utilizes the angiotensin-converting enzyme 2 receptor to enter host cells.

Purpose of the Study:

  • To elucidate the precise mechanisms of COVID-19 pathogenesis.
  • To review and suggest effective pharmacological and nutritional treatment regimens for COVID-19 management.

Main Methods:

  • Review of existing scientific literature on COVID-19 mechanisms.
  • Analysis of viral entry pathways and cellular responses.
  • Compilation of proposed therapeutic strategies.

Main Results:

  • Viral entry involves binding to angiotensin-converting enzyme 2, followed by host cell DNA replication.
  • Infection triggers severe hypoxia, lung oxidative stress via reactive oxygen species, and immune system overactivation.
  • Pharmacological and nutritional interventions are suggested based on understanding these mechanisms.

Conclusions:

  • Understanding the detailed mechanisms of COVID-19 infection is crucial for effective treatment.
  • Targeting viral entry, oxidative stress, and immune responses may offer therapeutic benefits.
  • A combination of pharmacological and nutritional approaches shows promise for managing COVID-19.
Keywords:
ACE2COVID-19immune mediatorsinhibitory mechanismspneumonia

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