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Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial
David S Khoury1, Pengxing Cao2, Sophie G Zaloumis3
1Kirby Institute, UNSW Sydney, Sydney, Australia.
Trends in Parasitology
|August 11, 2020
Abstract:
Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.
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