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Case-fatality From Orally-transmitted Acute Chagas Disease: A Systematic Review and Meta-analysis
Eduardo G Bruneto1, Miguel M Fernandes-Silva2, Cristina Toledo-Cornell3
1Federal University of Acre, Rio Branco, Brazil.
Summary
Orally-transmitted acute Chagas disease (CD) has a significant fatality rate, but this has decreased over time. This study analyzes 2470 cases, finding a 1.0% case-fatality rate for oral CD.
Area of Science:
- * Infectious Diseases
- * Public Health
- * Epidemiology
Background:
- * Orally-transmitted acute Chagas disease (CD) is a growing public health concern.
- * Prognosis and lethality data for acute oral CD are limited.
- * Understanding oral transmission dynamics is crucial for disease control.
Purpose of the Study:
- * To analyze and summarize data on orally-transmitted acute Chagas disease.
- * To estimate the case-fatality rate of acute oral CD.
- * To assess trends in lethality over time.
Main Methods:
- * Systematic literature review of publications from 1968 to January 2018.
- * Inclusion of unpublished data from government sources.
- * Meta-analysis of 2470 reported cases of acute orally-transmitted CD.
Main Results:
- * A total of 2470 cases and 97 deaths were analyzed.
- * The estimated case-fatality rate for acute oral CD was 1.0% (95% CI 0.0-4.0%).
- * A statistically significant decline in lethality rates over time was observed (P = .02).
Conclusions:
- * Orally-transmitted acute Chagas disease exhibits considerable lethality within the first year of infection.
- * Lethality in symptomatic orally-acquired cases is comparable to other transmission routes.
- * The lethality rate of orally-acquired Chagas disease has decreased over the years.
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