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S100B protein: general characteristics and pathophysiological implications in the Central Nervous System
Ana Cristina Arrais1, Lívia Helena M F Melo1, Bianca Norrara1
1Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoró, RN, Brazil.
The International Journal of Neuroscience
|August 11, 2020
Summary
The S100B protein, a calcium-binding protein in the Central Nervous System (CNS), plays a role in regulating physiological processes and acts as a marker and signaling molecule during CNS injury.
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Background:
- Calcium-binding proteins are diverse and perform numerous functions by binding calcium ions.
- S100B is a significant calcium-binding protein with critical roles in cellular processes.
Purpose of the Study:
- To review the S100B protein in the Central Nervous System (CNS).
- To highlight its characteristics, distribution, functions, and implications in CNS dysfunction.
Main Methods:
- Literature search of major scientific databases (PubMed, Medline, Science Direct, Lilacs, Cochrane Library, Web of Science).
- Utilized keywords: S100 protein, Central Nervous System, Nervous Lesions, and their translations.
Main Results:
- S100B protein regulates intra- and extracellular physiological processes due to its calcium-binding ability.
- S100B functions as both a marker and signaling molecule, aiding in the detection and protection of CNS injury.
Conclusions:
- Further research is needed to uncover the full range of S100B protein's actions.
- Elucidating its functions may reveal therapeutic potential for CNS conditions in preclinical and clinical settings.
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