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Genetic factors in anthracycline-induced cardiotoxicity in patients treated for pediatric cancer
Kateryna Petrykey1,2, Gregor U Andelfinger3,4, Caroline Laverdière1,3
1Immune Diseases and Cancer, Sainte-Justine University Health Center (SJUHC) , Montreal, Quebec, Canada.
Introduction:
Cardiovascular diseases are the main cause of treatment-related morbidity and mortality in childhood cancer patients. Anthracyclines, one of the most common chemotherapeutic agents in treatment regimens, are implicated in chemotherapy-induced cardiotoxicity.
Areas Covered:
This review describes the pharmacogenomic markers related to anthracycline-induced cardiotoxicity affecting childhood cancer patients. We also included a brief overview of the applicability of reported findings to the well-established PETALE cohort of childhood acute lymphoblastic leukemia survivors of the Sainte-Justine University Health Center (Canada).
Expert Opinion:
The wide variation in interindividual susceptibility to anthracycline-induced cardiotoxicity, along with a multitude of genetic variants detected through association studies, suggests that genetic contributions could be essential for the design of new individualized preventive approaches.
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