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Related Experiment Videos

Cortical flow in animal cells.

D Bray1, J G White

  • 1MRC Cell Biophysics Unit, London, United Kingdom.

Science (New York, N.Y.)
|February 19, 1988
PubMed
Summary
This summary is machine-generated.

Actin filament flow in the cell cortex drives animal cell movements like locomotion and cytokinesis by creating tension gradients. This continuous cycle of cortical components powers various cellular dynamics.

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Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Cellular movements are fundamental to animal life.
  • The mechanisms driving these movements, particularly the role of the cell cortex, are complex and not fully understood.

Purpose of the Study:

  • To elucidate the role of actin filament flow in the cell cortex as a driving force for animal cell movements.
  • To explain how tension gradients in the cell cortex contribute to cellular dynamics.

Main Methods:

  • The study proposes a model based on the concerted flow of actin filaments.
  • It analyzes the role of tension gradients in the cell cortex.
  • It considers the return of cortical components through the cytoplasm.

Main Results:

  • A concerted flow of actin filaments along the plasma membrane is identified as a key mechanism.

Related Experiment Videos

  • Gradients of tension in the cell cortex were found to drive the movement of cortical components.
  • This cortically located motor system supports cell locomotion, growth cone migration, antigen capping, and cytokinesis.

    • Conclusions:

    • The flow of actin filaments in the cell cortex acts as a universal motor for diverse animal cell movements.
    • Understanding cortical tension dynamics is crucial for comprehending cell motility and division.