A case series of children with adenovirus pneumonia: three-year experiences in a tertiary PICU

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Jingyi Shi1, Yiping Zhou1, Fei Wang1

  • 1Department of Critical Care Medicine, Shanghai Children's Hospital; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, No.355 Luding Road, Putuo District, Shanghai, 200062, China.

BMC Pediatrics
|August 11, 2020
PubMed

Insights

Adenovirus pneumonia in children admitted to the pediatric intensive care unit (PICU) resulted in a 16.42% hospital mortality rate. Liver dysfunction and nosocomial infections were identified as key risk factors for poor outcomes in these severe cases.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Respiratory medicine

Background:

  • Adenovirus pneumonia is a significant cause of respiratory illness in children.
  • Severe cases require admission to the pediatric intensive care unit (PICU) for acute hypoxemic respiratory failure.
  • Understanding outcomes and risk factors is crucial for improving patient management.

Purpose of the Study:

  • To describe the outcomes of adenovirus pneumonia in a PICU over a three-year period.
  • To identify risk factors associated with worse outcomes in pediatric patients with severe adenovirus pneumonia.
  • To inform clinical practice and improve survival rates.

Main Methods:

  • A retrospective observational study was conducted in a pediatric hospital PICU from July 2016 to June 2019.
  • Included were 67 children (29 days to 14 years) with adenovirus pneumonia and acute hypoxemic respiratory failure.
  • Primary outcome was hospital mortality; secondary outcomes included length of stay and risk factors for mortality.

Main Results:

  • Hospital mortality was 16.42% (11/67), with 28-day mortality at 14.93% (10/67).
  • Median PICU length of stay (LOS) was 11 days, and hospital LOS was 22 days.
  • Multivariate analysis identified liver dysfunction and nosocomial infection as significant risk factors for mortality.

Conclusions:

  • The hospital mortality rate for severe adenovirus pneumonia in this PICU cohort was 16.42%.
  • Liver dysfunction and co-infections/nosocomial infections are associated with poor outcomes.
  • Early identification and management of these complications are critical for improving pediatric patient survival.
Abstract

Keywords:
Adenovirus pneumoniaMortalityOutcomePediatric intensive care unit (PICU)

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