Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple system organ failure.

D E Fry1

  • 1Case Western Reserve University, Cleveland, Ohio.

The Surgical Clinics of North America
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Severe infections can lead to multiple system organ failure and high mortality rates, exceeding 50%. New treatments are urgently needed to address the complex immune and biochemical processes involved in this critical condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The alimentary absorption of diamorphine and morphine in man as indicated by urinary excretion studies.

British journal of clinical pharmacology·2012
Same author

Profile. Donald E. Fry. Interview by Vicki Glaser.

Surgical infections·2005
Same author

Basic aspects of and general problems in surgical infections.

Surgical infections·2003
Same author

Herpesviruses: emerging nosocomial pathogens?

Surgical infections·2003
Same author

Multiple organ dysfunction syndrome: past, present and future.

Surgical infections·2003
Same author

The consequences of suppression of anaerobic bacteria.

Surgical infections·2003
Same journal

Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

Beyond the Scalpel's Reach.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Society.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Hospitals.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions for Providers.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
See all related articles

Area of Science:

  • Critical care medicine
  • Immunology
  • Pathophysiology

Background:

  • Multiple system organ failure (MSOF) is a common fatal outcome in severe infections.
  • Despite advanced life support, MSOF mortality remains above 50%.

Purpose of the Study:

  • To highlight the critical need for novel therapeutic strategies.
  • To emphasize the complexity of MSOF pathogenesis involving numerous mediators.

Main Methods:

  • Review of existing literature on MSOF.
  • Analysis of the role of various mediators and effectors in MSOF development.

Main Results:

  • MSOF is a complex process with numerous unidentified interacting mediators.
  • Current understanding of mediator interactions in MSOF is incomplete.

Related Experiment Videos

Conclusions:

  • Future therapies must target host immunomodulation and biochemical processes.
  • Significant improvements in MSOF outcomes require addressing these fundamental mechanisms.