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Published on: December 5, 2020
Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in
Di Luo1, Ji-Zhao Xie1, Lu-Hui Zou1
1School of Pharmaceutical Science, Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, China.
Abstract:
Five previously undescribed lanostane-type triterpenoids, including two triterpenoids with a rearranged side chain (applanoic acids E and F), one C21 nortriterpenoid (16,17-dehydroapplanone E), as well as two highly oxygenated lanostane triterpenoids (methyl applaniate B and applanoic acid G), were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography and ECD data. Applanoic acid E, 16,17-dehydroapplanone E, and methyl applaniate B showed inhibitory effects on the release of NO by LPS-induced BV-2 cells.
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