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Thromboembolic events and Covid-19.
Agnès Ribes1, Fanny Vardon-Bounes2, Vincent Mémier3
1Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
Advances in Biological Regulation
|August 11, 2020
Summary
COVID-19 causes severe respiratory issues and blood clotting problems. This review covers blood clot risks, clotting changes, and inflammation in COVID-19 patients, exploring anticoagulant treatments.
Area of Science:
- Infectious Diseases
- Hematology
- Pulmonology
Background:
- COVID-19, caused by SARS-CoV-2, presents a significant global health challenge.
- Severe cases often involve acute respiratory failure and systemic coagulopathy.
- The virus targets the lungs, leading to acute respiratory distress syndrome and a thromboinflammatory state.
Purpose of the Study:
- To review thromboembolic manifestations in COVID-19.
- To summarize disturbed hemostatic parameters associated with the disease.
- To discuss anticoagulant and antithrombotic treatment options.
Main Methods:
- This is a review article.
- It synthesizes current knowledge on COVID-19's impact on hemostasis and thrombosis.
- It discusses therapeutic strategies.
Main Results:
- COVID-19 is associated with a high frequency of thromboembolic events, even with anticoagulation.
- Elevated D-dimers and thrombocytopenia are linked to increased mortality.
- Thromboinflammation and pulmonary tropism contribute to severe disease and organ failure.
Conclusions:
- COVID-19 induces a prothrombotic state with significant clinical implications.
- Understanding these thromboinflammatory conditions is crucial for patient management.
- Further research into optimal antithrombotic therapies is warranted.
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