Related Experiment Video

Updated: Dec 12, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.1K

Evaluation of coagulation status using viscoelastic testing in intensive care patients with coronavirus disease 2019

Luke Wallace Collett1, Samuel Gluck1, Richard Michael Strickland1

  • 1Intensive Care Unit, Royal Adelaide Hospital, Adelaide, SA, Australia; School of Acute Medicine, University of Adelaide, Adelaide, SA, Australia.

Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses
|August 11, 2020
PubMed

Insights

Critically ill COVID-19 patients show a hypercoagulable state, not detected by standard tests. Viscoelastic testing reveals supranormal clot firmness and minimal lysis, indicating a need for further research into anticoagulation strategies.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Coronavirus Disease-19 (COVID-19) is linked to significant thrombosis.
  • The exact pathophysiology of COVID-19-associated thrombosis remains unclear.
  • Viscoelastic testing offers a method to characterize hypercoagulable states beyond conventional assays.

Purpose of the Study:

  • To evaluate the coagulation status in critically ill adults with COVID-19-associated respiratory failure using viscoelastic testing.
  • To compare viscoelastic findings with conventional coagulation markers.

Main Methods:

  • Single-center observational point prevalence cohort study.
  • Inclusion of adult patients with COVID-19-associated respiratory failure requiring intensive care unit (ICU) respiratory support.
  • Coagulation status assessed using rotational thromboelastometry (ROTEM®) alongside laboratory markers.

Main Results:

  • All six included patients demonstrated supranormal clot amplitude (A10) and clot firmness on ROTEM®.
  • Five patients showed supranormal firmness across all ROTEM® pathways.
  • Minimal clot lysis was observed in all patients, with elevated fibrinogen and D-dimer levels despite normal routine coagulation markers.

Conclusions:

  • Critically ill COVID-19 patients exhibit a hypercoagulable state not evident through conventional coagulation tests.
  • Key findings include supranormal clot firmness, minimal fibrinolysis, and hyperfibrinogenaemia.
  • Further investigation is needed into the underlying pathophysiology and optimal anticoagulation strategies for this condition.
Abstract

Keywords:
ARDSCOVID-19CoronavirusRotational thromboelastometryViscoelastic testing

More Related Videos

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

2.0K
In Vitro Thrombosis Test for Ventricular Assist Devices09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.0K

Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.2K
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.0K
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
180
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
122
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
154
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
94