Chronic axonal idiopathic polyneuropathy: is it really benign.

Area of Science:

• Neurology
• Clinical Medicine

Background:

• Chronic idiopathic axonal polyneuropathy (CIAP) is a prevalent neurological disorder.
• While often viewed as benign with low disability risk, CIAP substantially affects patients' quality of life and daily functioning.

Purpose of the Study:

• To review recent findings on chronic idiopathic axonal polyneuropathy (CIAP).
• To summarize current knowledge regarding risk factors, comorbidities, and pathogenic mechanisms of CIAP.

Main Methods:

• Literature review of recent studies on CIAP.
• Synthesis of data on clinical manifestations, patient-reported outcomes, and potential therapeutic strategies.

Main Results:

• CIAP patients exhibit impaired walking, balance issues, and increased fall risk.
• Neuropathic pain affects approximately two-thirds of CIAP patients, correlating with increased fatigue and emotional distress.
• Plantar ulcers, neuropathic arthropathy, and small fiber involvement are observed in CIAP.

Conclusions:

• CIAP leads to significant life limitations, including reduced mobility and pain, despite mild motor impairment.
• The unclear pathogenesis of CIAP precludes disease-modifying treatments.
• Further research into CIAP pathogenesis and randomized controlled trials for treatment options are essential.