Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucagon secretion in anorexia nervosa.

M Kumai1, H Tamai, S Fujii

  • 1Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The American Journal of Clinical Nutrition
|February 1, 1988
PubMed
Summary

Anorexia nervosa patients show abnormal pancreatic alpha- and beta-cell responses, leading to impaired glucose tolerance. Treatment improves glucose regulation by normalizing these pancreatic cell functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Supine-Use Wearable Cyborg for Treatment of Neurogenic Bowel Dysfunction after Spinal Cord Injury.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

A nationwide survey of pediatric acquired demyelinating syndromes in Japan.

Neurology·2016
Same author

Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia.

Leukemia·2015
Same author

Development of low-fluorescence thick photoresist for high-aspect-ratio microstructure in bio-application.

Biomicrofluidics·2015
Same author

Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice.

Bone marrow transplantation·2014
Same author

Optimal administration time of intramuscular midazolam premedication.

Journal of anesthesia·2013

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Nutritional Psychiatry

Background:

  • Anorexia nervosa is often associated with impaired glucose tolerance.
  • Dysregulation of pancreatic glucagon secretion is linked to diabetes mellitus.
  • Understanding pancreatic islet cell function in anorexia nervosa is crucial for metabolic health.

Purpose of the Study:

  • To investigate pancreatic alpha- and beta-cell responses to glucose load in patients with anorexia nervosa.
  • To compare these responses before and after treatment for anorexia nervosa.
  • To elucidate the relationship between pancreatic cell function and impaired glucose tolerance in anorexia nervosa.

Main Methods:

  • Assessed pancreatic alpha- and beta-cell function via glucose challenge tests in 25 anorexic patients and controls.

Related Experiment Videos

  • Measured plasma glucagon and insulin levels.
  • Evaluated glucose tolerance before and after therapeutic intervention.

    • Main Results:

    • Baseline glucose challenge failed to suppress plasma glucagon in anorexic patients, unlike controls and treated patients.
    • Anorexic patients exhibited higher plasma glucose levels during baseline challenges, which normalized post-treatment.
    • Insulin responses were lower in anorexic patients compared to controls, both at baseline and after treatment.

    Conclusions:

    • Impaired glucose tolerance in anorexia nervosa is linked to significant alterations in pancreatic alpha- and beta-cell secretions.
    • Dysfunctional pancreatic alpha-cell and glucose interrelationships contribute to metabolic disturbances in anorexia nervosa.
    • Treatment of anorexia nervosa can lead to improvements in pancreatic cell function and glucose regulation.