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Nonadherence in bipolar disorder patients: A 14-year retrospective study
Dinesh Narayanan1, Arya Jith1, Rahul Bansal1
1Department of Psychiatry, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Indian Journal of Psychiatry
|August 11, 2020
Summary
Nonadherence is common in bipolar disorder, with poor understanding of illness and negative drug perceptions being key factors. However, most patients achieve over 80% medication adherence long-term.
Area of Science:
- Psychiatry
- Pharmacology
- Public Health
Background:
- Bipolar disorder significantly impacts patients, with high rates of nonadherence reported.
- Nonadherence contributes to relapses, delayed recovery, and increased healthcare costs.
- Determinants of nonadherence in bipolar affective disorder (BPAD) require further clarification.
Purpose of the Study:
- To determine the prevalence of nonadherence in BPAD patients.
- To identify factors associated with nonadherence in this population.
Main Methods:
- Retrospective review of medical records from 2005-2019.
- Inclusion of 150 patients diagnosed with BPAD (ICD-10) requiring prophylaxis.
- Definition of nonadherence as missing medication for at least one week.
Main Results:
- 82.7% of patients had a history of noncompliance for at least one week.
- Primary reasons for nonadherence included poor family understanding (56%) and negative patient drug perception (20%).
- Statistical analysis used the Chi-square test for categorical variables.
Conclusions:
- Despite a high history of temporary nonadherence, most BPAD patients demonstrate over 80% long-term medication adherence.
- Addressing family understanding and patient drug attitudes may improve adherence.
- Long-term follow-up reveals a generally positive adherence trend.
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