Appraisal of radioiodine refractory thyroid cancer: advances and challenges

The incidence of thyroid cancer ranks top among all endocrine cancers, which has increased worldwide. Some patients suffer from recurrent/residual diseases after primary treatment. The recurrent/residual disease often turns out to be radioiodine refractory and shows poor response to radioiodine therapy. A lot of studies have explored the precise appraisal of radioiodine refractory disease in recent years. The mechanism of iodine uptake and the definition of radioiodine refractory disease have been summarized and discussed. The advances in tumor characteristics, histologies, and mutant conditions have been explored for a more accurate method in the early-stage appraisal. We then offer a review of opinions in the evaluation of refractory disease during follow-up, including Tg doubling time, ¹⁸F PET/CT, ¹³¹I WBS, and others. The sensitivity and specificity have been compared between different diagnostic methods. Some novel methods may be introduced for more precise appraisal, such as a scoring system and RNA expression profiling. This review aims to provide physicians a broad insight into the appraisal of radioiodine refractory disease and to pave way for future study.