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Updated: Dec 12, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Meningoencephalitis from SARS-CoV-2 infection.

Fatima Hafizi¹, Saleema Kherani¹, Madeeha Shams²

¹MedStar Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, United States.

|August 11, 2020

Summary

A rare case of meningoencephalitis, a brain and spinal cord inflammation, was linked to COVID-19. This neurological complication, presenting with altered mental status and limb movements, highlights the diverse symptoms of coronavirus disease.

Keywords:

COVID-19 CSF Coronavirus Meningoencephalitis Nervous system SARS-CoV-2

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Area of Science:

Neurology
Infectious Diseases
Virology

Background:

The global COVID-19 pandemic, caused by SARS-CoV-2, primarily presents as severe respiratory illness.
However, diverse clinical manifestations affecting multiple organ systems have been increasingly reported.
Neurological complications are recognized but remain less understood.

Observation:

A 35-year-old woman presented with acute meningoencephalitis, characterized by altered mental status and involuntary rhythmic limb movements.
Cerebrospinal fluid analysis and clinical presentation were consistent with central nervous system inflammation.
SARS-CoV-2 infection was confirmed concurrently.

Findings:

This case demonstrates a direct association between COVID-19 and meningoencephalitis.
The neurological symptoms, including altered mental status and myoclonus, were prominent features.
The patient's recovery trajectory related to the neurological symptoms requires further monitoring.

Implications:

Meningoencephalitis should be considered in the differential diagnosis of new-onset neurological symptoms during the COVID-19 pandemic.
This case underscores the neurotropic potential of SARS-CoV-2.
Further research is needed to elucidate the mechanisms of SARS-CoV-2-induced neurological damage and long-term outcomes.