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Idiopathic nodular glomerulosclerosis and differential diagnosis
Sergio Raúl Alvizures Solares1,2, Héctor Raúl Ibarra-Sifuentes1,2, María Guadalupe Ramírez Ramírez1,2
1Universidad Autónoma de Nuevo León, University Hospital, Internal Medicine Department, Monterrey, México.
Introduction:
Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern.
Case Presentation:
The authors present the case of a 44-year-old Hispanic smoker female with hypertension and peripheral arterial disease who presented nephrotic syndrome for 2 weeks. The patient was diagnosed with ING by percutaneous renal biopsy results, which showed global nodular mesangial matrix expansion, with linear staining accentuation of glomerular and tubular basement membrane for Immunoglobulin G (IgG) and albumin on immunofluorescence.
Conclusions:
ING is a rare disease with a poor renal prognosis and wide diagnostic approach; we highlight the importance of analyzing every piece of detail together to reach a definitive diagnosis.
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