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Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy

S Ciardullo1,2, F Zerbini2, S Perra2

  • 1Department of Medicine and Surgery, Università degli Studi di Milano Bicocca, Milan, Italy.

Journal of Endocrinological Investigation
|August 11, 2020
PubMed

Insights

Patients with pre-existing diabetes admitted for Coronavirus Disease 2019 (COVID-19) faced higher in-hospital mortality. This finding highlights the need for closer monitoring of diabetic individuals during the COVID-19 pandemic.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Endocrinology

Background:

  • Coronavirus Disease 2019 (COVID-19) is a global health crisis.
  • Comorbidities, such as diabetes, may influence COVID-19 patient outcomes.
  • Understanding risk factors for mortality is crucial for patient management.

Purpose of the Study:

  • To investigate the association between pre-existing diabetes and in-hospital mortality in COVID-19 patients.
  • To identify if diabetes independently predicts mortality in hospitalized COVID-19 cases.

Main Methods:

  • Retrospective, single-center study of 373 adult patients hospitalized with COVID-19.
  • Data collected included diabetes status, comorbidities, and laboratory results.
  • Multivariable logistic regression analysis was used to assess the impact of diabetes on mortality.

Main Results:

  • 18.5% of patients had pre-existing diabetes.
  • In-hospital mortality was 38.0% among all patients.
  • Diabetes was independently associated with increased in-hospital mortality (RR 1.56 [1.05-2.02]), alongside older age and COPD.

Conclusions:

  • Pre-existing diabetes is an independent risk factor for higher in-hospital mortality in COVID-19 patients.
  • Diabetic patients hospitalized with COVID-19 require more intensive monitoring.
  • Further research into managing diabetic patients with COVID-19 is warranted.
Abstract

Keywords:
COVID-19CoronavirusDiabetesMortalitySARS-CoV-2

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