Metagenomics analysis of intestinal flora modulatory effect of green tea polyphenols by a circadian rhythm...

The present study investigated the regulatory mechanism of green tea polyphenols (GTP) on the circadian rhythm of gut flora. The administration of GTP mitigated the variations in the serum and liver level of constant dark (CD)-induced circadian rhythm disorder mouse model. For the gut microbial population, GTP promoted the relative abundance of Bacteroidetes while inhibited Firmicutes. Furthermore, KEGG pathways of biosynthesis of amino acids, two-component system and ATP-binding cassette translocators enriched the most differentially expressed genes after GTP interference. It indicated GTP may prevent CD-induced circadian rhythm disorder, which has an enormous potential to be utilized as prebiotic-like ingredients in food industry. PRACTICAL APPLICATIONS: The findings underscore the capacity of GTP to modulate circadian rhythm by modulating the structure and functional characteristics of host gut microbiota and influencing metabolism, conducing to the melioration of human microecology. The prebiotic function of GTP indicated it can be used to prevent metabolic disturbance related to circadian rhythm disorder.